HIIT vs. Strength: Just One Session Could Activate Anti-Cancer Proteins

What if one workout could do more than boost your strength, improve your endurance, or help you sleep better? What if it could actually help your body fight cancer?

It sounds almost too good to be true, but according to new research, that’s exactly what happens. A single session of resistance training or high-intensity interval training (HIIT) can trigger powerful biological changes that make your body better at suppressing cancer cell growth. For breast cancer survivors in particular, this could be a groundbreaking finding.

We’ve long known that exercise reduces the risk of many chronic diseases, but scientists are now uncovering its role as an active, cancer-fighting ally. This study1 offers a hopeful glimpse at how movement can immediately shift the body’s internal chemistry in protective ways.

Inside the study

Researchers recruited 32 women who had survived breast cancer. Half were assigned to do a session of resistance training (think weight lifting), while the other half did a session of HIIT (short bursts of intense cardio with rest periods in between).

The scientists took blood samples before the workout, immediately afterward, and again 30 minutes later. They weren’t just looking at heart rate or calories burned. Instead, they measured something called myokines, small proteins released by muscles during exercise that act like messengers, influencing different systems in the body. Some of these myokines, including IL-6, SPARC, decorin, and oncostatin M, have been shown in lab settings to suppress cancer cell growth.

To test this directly, the researchers applied the participants’ post-workout blood samples to aggressive breast cancer cells grown in the lab. Then they watched what happened.

Exercise as a cancer fighter

Just one workout was enough to shift the body’s internal chemistry in powerful ways:

In other words, the body doesn’t need months or years of training to produce this effect. Even a single bout of exercise can immediately tip the scales in favor of cancer suppression.

What this means for you

While this study focused on breast cancer survivors, the findings have broad implications for anyone interested in cancer prevention and overall health. Here are the key takeaways:

The takeaway

This study is a reminder that movement is medicine, sometimes in ways we can feel, and sometimes in ways we can’t see. By simply moving your body, you’re prompting your muscles to release signals that can help slow down cancer cell growth.

That’s a powerful motivation to lace up your sneakers. Whether you choose a HIIT session, lift some weights, or combine the two, you’re doing more than working out; you’re giving your body tools to fight for your health.